What is Kisspeptin-10
Kisspeptin-10 (also known as Metastin) is the C-terminal decapeptide of the KISS1 precursor and a strong endogenous ligand of GPR54 / KISS1R. In preclinical investigations, it promotes GnRH release, which leads to downstream LH and FSH production, making it a valuable tool in reproductive endocrinology and hypothalamic-pituitary-gonadal (HPG) axis research.
Kisspeptin signaling has also been linked to metabolic regulation, neurobehavioral functions, angiogenesis, and anti-metastatic activities in tumor models.
Key Research Benefits
- Directly activates GPR54/KISS1R for receptor signaling studies
- Stimulates GnRH release to investigate HPG axis function
- Triggers LH/FSH secretion in preclinical models
- Pubertal onset and fertility mechanism research
- Infertility and spermatogenesis research tool
- Metabolic and energy-balance research (glucose, appetite)
- Neurobehavioral and mood studies
- Angiogenesis and cancer biology research
- Biomarker and diagnostic research utility
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